ABSTRACT
Four known flavonoids: quercetin 3-O-beta-D-rutinoside [Q3Rut], myricetin 3-O-betaD-galactopyranoside [M3Gal], quercetin 3-O-beta-D-galactopyranoside [Q3Gal] and quercetin 3-Obeta-D-glucopyranoside [Q3Glc], for the first time were isolated from aerial parts of Euphorbia microsciadia. The chemical structure of them was elucidated on the basis of 1 and 2 D-NMR spectra and different spectroscopic techniques. The immunomodulatory activities of isolated compounds were compared using standard T-cell proliferation assay. These data showed that lymphocyte suppression activity of flavonoids [1-4] were comparatively lower than prednisolon as a standard drug. Immunosuppressive activity of flavonoids with hydroxyl groups at both 3'-and 4'-positions in their B-ring [Q3Gal] were more than those with 3'-, 4'-and 5'-hydroxyl substitution [M3Gal]. In these compounds, Q3Gal showed the most inhibitory activity, whereas M3Gal showed the least lymphocyte antiprolifeartive activity
ABSTRACT
The glucosinolate autolysis products of crushed seeds of Descurainia sophia L. [khakeshi] and Brassica napus L. [shelghem] were administered orally to rats in doses representing 8, 16 and 32gm seeds/kg body weight/day at intervals of 10,20 and sometimes 30 days. Serum T3 and T4 concentrations were reduced in 10 day-autolysate treated animals in a similar fashion to that found with methimazole. The antithyroid effect persisted until day 20, but was weaker than that seen with methimazole. By day 30, serum T3 and T4 concentrations returned to normal in plant treated animals